Side effects should also be monitored and your veterinarian should be notified of any seizure activity your pet experiences or any side effects that occur. The review considers the appropriate use of antiepileptic drugs: phenobarbitone and potassium bromide are effective in most canine patients, although dosing regimes need to be carefully tailored to the individual, with serum concentration measurement. /MEDICATION:VET/ Bromide treatment was successful in controlling seizures in an 11-year-old Dachshund with epilepsy and presumptive phenobarbital-associated hepatopathy. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Discontinuation of barbiturate treatment was possible in 19% of those dogs originally treated with phenobarbital or primidone. Potassium bromide was tried for two children with daily convulsive focal motor seizures with unconsciousness and focal motor seizure status. It is frequently used together with Phenobarbital but may be used by itself to control seizure activity as well. High-dose phenobarbital therapy successfully controlled the convulsions, but was discontinued because of drug-induced aplastic anemia. However, a significant proportion of patients remains refractory to these drugs. The diet of a dog or cat receiving potassium bromide should not be altered without speaking first with your veterinarian. Capillary electrophoresis, the separation of double stranded DNA, uses potassium buffer solutions. Work is currently underway to test the efficacy of newer antiepileptic drugs in the treatment of canine epilepsy, and preliminary data suggest that human drugs such as levetiracetam and gabapentin are of benefit in dogs with refractory epilepsy. In this dog, institution of a special calculolytic diet with high chloride content was associated with a decrease in serum bromide concentrations and the recurrence of seizures. vitamins, herbal supplements, etc. Alternative bromide therapy was markedly effective in controlling the seizures. A 3-year-old Japanese girl with severe epilepsy had been treated with potassium bromide since August 1999. Accessed May 02, 2020. Administration of KBr was associated with significant but transient changes in serum potassium and sodium concentrations, and possible changes in base excess and plasma bicarbonate concentrations. Because it stains the skin and it's toxicity if taken internally, there are many more effective and safer options. Trademarks & Tradenames used herein are the property of their respective holders. Gleason. The pharmacokinetics of a multidose regimen of potassium bromide (KBr) administration in normal dogs was examined. Potassium bromide salt plates are used because they have the desired feature of being soft and hygroscopic--able to attract water molecules 13. Seizures in cats and horses can also be treated and controlled with potassium bromide, but because of the incidence of side effects, particularly in cats, it is rarely used 13. US residents can call their local poison control center at 1-800-222-1222. CONCLUSIONS: and clinical relevance Loading doses of 120 mg/kg daily over 5 d and maintenance doses of approximately 90 mg/kg of KBr administered once daily resulted in serum bromide concentrations consistent with therapeutic efficacy for the management of seizures in other species. In 1857, Sir Charles Locock discovered the anti-convulsant and sedative activity of potassium bromide in humans 13. What precautions should you take while using Potassium Bromide? "Potassium Bromide - Uses, Side-effects, Reviews, and Precautions - TabletWise" Tabletwise.