Vet Dermatol. For the purpose of this study, articles on feral animals or wildlife not infected with S. scabiei were excluded from analysis. Whilst comprehensive reviews have been published on the pathogenesis and epidemiology of sarcoptic mange in wildlife [2, 11], to our knowledge no review has focussed specifically on methods of treatment and their long-term outcomes. The majority of studies were undertaken in Australia, Europe and Africa (Table 1). The authors of this review do not recommend extrapolating regimens involving ivermectin to other macrocyclic lactones and vice versa. This study was subsequently included in both of these analysis groups; hence the cumulative number of studies under the captive and free-ranging treatment group headings in Fig. One must also question the ethics of treating endemic diseases in free-ranging wildlife with a healthy conservation status; whilst the presentation of sarcoptic mange may raise welfare concerns, it is possible that resultant deaths play a role in natural selection for resistant animals. Mange is currently the subject of much research in the wildlife world; learn more about this emerging disease and the Wildlife Center’s research on mange treatment. Schultz RN, Wydeven AP, Stewart JM. Ivermectin featured in all studies.  warned that only drugs known to have a broad therapeutic margin should be used, as highly precise drug dosages cannot be ensured when delivering medication through feed to free-ranging animals. Isoxazolines: a novel chemotype highly effective on ectoparasites. has reported successful treatment of S. scabiei in an American black bear using a single oral dose of 44 mg/kg . OIE Media. Intas Polivet. Mange can be successfully treated by administering medication that kills the mites. Veterinarians are divided on the best treatment for … OIE World Organisation for Animal Health. Ivermectin was delivered between 1–7 times, with an average of 1.8 times and a median of 1 time. Studies that failed to identify S. scabies as the source of infection prior to treatment, or which did not document treatment outcomes or a post-treatment monitoring period were excluded from further analysis. Of the remaining 24 studies, only three studies specifically monitored for or stated an absence of deleterious side effects following treatments [21,22,23]. , may be a more appropriate action to relieve suffering and reduce the transmission of disease. Twenty-eight studies met our initial inclusion criteria for data collection. Severely affected animals may not survive despite treatment; while the mites may be killed with the medication, the animal’s body condition and overall health may be too comprised for recovery. 2014;76:1169–72.  hypothesise that reducing the average intensity of infection to a low level will halt the transmission of S. scabiei. mild, moderate or severe) was extrapolated from descriptions of the severity and distribution of mange lesions over the body of infected animals. If you see a wild animal with scattered patches of missing hair, a thin or hairless tail, itching, and especially with squinted eyes, it has mange. Ruykys L, Breed B, Schultz D, Taggart D. Effects and treatment of sarcoptic mange in southern hairy-nosed wombats (Lasiorhinus latifrons). Vet Rec. Menzano A, Rambozzi L, Min ARM, Meneguz PG, Rossi L. Description and epidemiological implications of S. scabiei infection in roe deer (Capreolus capreolus) originating from chamois (Rupicapra rupicapra). Most studies were published following the year 2000, although in several cases the research start date was many years earlier than this. There is an imperative need for larger and more definitive randomised controlled studies. Based on the findings of this review, there is a low chance that captive wildlife from which mange has been successfully eliminated by treatment with ivermectin or fluralaner will redevelop mange whilst remaining in captivity; only one of the ten studies involving the treatment of wildlife in captivity reported a relapse of mange during their post-treatment observational period . If re-infection rates are high and survival rates are poor post-release, euthanasia and removal of infected bodies from the environment, as demonstrated in a study by Alasaad et al.